What Is the Strongest Weight Loss Prescription Pill? Quick answer: The most powerful prescription treatments for weight loss today are the GLP‑1/GIP–based injectables (e.g., tirzepatide; semaglutide). If you’re asking strictly about a pill, the prescription options with the strongest average results are typically phentermine/topiramate (Qsymia) and naltrexone/bupropion (Contrave), with orlistat also used for fat‑absorption blocking. […]
